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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Frk
Name: fyn-related Src family tyrosine kinase
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Frkincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of FRK mRNAPMID:21215274
Frkaffects expressionISOFrk (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of FRK mRNAPMID:21570461
Frkdecreases expressionISOFRK (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of FRK mRNAPMID:11007951 PMID:19619570 PMID:19901195
Frkmultiple interactionsISOFRK (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of FRK mRNA; Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of FRK mRNA]PMID:11007951 PMID:19619570
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