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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620596
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccr5
Name: C-C motif chemokine receptor 5
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccr5affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of CCR5 mRNAPMID:34747641
Ccr5decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of CCR5 mRNAPMID:32109520
Ccr5affects expressionISOCcr5 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of CCR5 mRNAPMID:21570461
Ccr5increases expressionISOCcr5 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of CCR5 mRNAPMID:18684927 PMID:21851831 PMID:24154488 PMID:26377647
Ccr5multiple interactionsISOCcr5 (Mus musculus)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCR5 mRNA]; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCR5 mRNA; Tetrachlorodibenzodioxin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of CCR5 mRNA]PMID:17942748 PMID:21851831
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