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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620528
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aox1
Name: aldehyde oxidase 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aox1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of AOX1 mRNAPMID:21215274 PMID:32109520
Aox1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of AOX1 mRNAPMID:20558275
Aox1affects expressionISOAox1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of AOX1 mRNAPMID:26377647
Aox1decreases expressionISOAOX1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of AOX1 mRNAPMID:23669205
Aox1decreases expressionISOAox1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of AOX1 mRNAPMID:33956508
Aox1increases activityISOAox1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased activity of AOX1 proteinPMID:16292751
Aox1increases expressionISOAOX1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of AOX1 mRNAPMID:19619570
Aox1increases expressionISOAox1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of AOX1 mRNA; Tetrachlorodibenzodioxin results in increased expression of AOX1 proteinPMID:15664268 PMID:16292751 PMID:20005886 PMID:21851831 PMID:26290441 PMID:28922406
Aox1multiple interactionsISOAOX1 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AOX1 mRNAPMID:19619570
Aox1multiple interactionsISOAox1 (Mus musculus)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of AOX1 mRNA]; [Tetrachlorodibenzodioxin co-treated with Vitamin A] results in increased activity of AOX1 protein; [Tetrachlorodibenzodioxin co-treated with Vitamin A] results in increased expression of AOX1 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of AOX1 mRNA; Tetrachlorodibenzodioxin promotes the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of AOX1 mRNA]; tungstate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AOX1 protein]; Vitamin A inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AOX1 protein]; Vitamin A inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AOX1 mRNA]PMID:15664268 PMID:16292751 PMID:21851831 PMID:25975270
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