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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619746
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gtf3a
Name: general transcription factor III A
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gtf3aincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of GTF3A mRNAPMID:33387578
Gtf3aaffects expressionISOGtf3a (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of GTF3A mRNAPMID:20702594 PMID:21570461 PMID:24058054
Gtf3adecreases expressionISOGtf3a (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of GTF3A mRNAPMID:15034205
Gtf3amultiple interactionsISOGtf3a (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of GTF3A mRNAPMID:16214954
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