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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61909
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1h3
Name: nuclear receptor subfamily 1, group H, member 3
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1h3increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of NR1H3 mRNAPMID:18796159 PMID:33387578 PMID:34747641
Nr1h3affects expressionISONr1h3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of NR1H3 mRNAPMID:21570461 PMID:24058054 PMID:36222588
Nr1h3decreases expressionISONr1h3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of NR1H3 mRNAPMID:19770486 PMID:28213091
Nr1h3increases expressionISONR1H3 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of NR1H3 mRNAPMID:19684285
Nr1h3multiple interactionsISONr1h3 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of NR1H3 mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NR1H3 mRNAPMID:17942748 PMID:23756648
Nr1h3multiple interactionsISONR1H3 (Homo sapiens)6480464CTD[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of NR1H3 mRNAPMID:19684285
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