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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 4892133
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ankhd1
Name: ankyrin repeat and KH domain containing 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:16166446480464CTDTetrachlorodibenzodioxin results in decreased expression of ANKHD1 mRNA

PMID:19770486
increases expressionISORGD:16166446480464CTDTetrachlorodibenzodioxin results in increased expression of ANKHD1 mRNA

PMID:21354282
multiple interactionsISORGD:16166446480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of ANKHD1 mRNA

PMID:25975270
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.