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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3770
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Star
Name: steroidogenic acute regulatory protein
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of STAR mRNA, Tetrachlorodibenzodioxin results in decreased expression of STAR protein

PMID:16141434, PMID:16254025, PMID:18637154, PMID:19276399, PMID:22493514, PMID:28070105
multiple interactionsEXP 6480464CTDFursultiamin inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of STAR mRNA], Gonadotropins, Equine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of STAR mRNA], Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of STAR mRNA]

PMID:16254025, PMID:19276399, PMID:28070105
decreases expressionISORGD:113506480464CTDTetrachlorodibenzodioxin results in decreased expression of STAR mRNA, Tetrachlorodibenzodioxin results in decreased expression of STAR protein

PMID:19933214, PMID:24793433
decreases expressionISORGD:7354136480464CTDTetrachlorodibenzodioxin results in decreased expression of STAR mRNA

PMID:30096437
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.