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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3738
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sp1
Name: Sp1 transcription factor
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sp1affects activityEXP 6480464CTDTetrachlorodibenzodioxin affects the activity of SP1 proteinPMID:11926288
Sp1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of SP1 mRNAPMID:33387578
Sp1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of SP1 mRNAPMID:34747641
Sp1affects expressionISOSp1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of SP1 mRNAPMID:21570461
Sp1decreases expressionISOSp1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of SP1 mRNAPMID:14708085 PMID:24058054
Sp1increases phosphorylationISOSP1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased phosphorylation of SP1 proteinPMID:20971882
Sp1multiple interactionsISOSp1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of SP1 mRNAPMID:15251184
Sp1multiple interactionsISOSP1 (Homo sapiens)6480464CTD[SP1 protein binds to CYP1B1 enhancer] promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [SP1 protein binds to CYP1A1 promoter]]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to SP1 protein]]PMID:12801909 PMID:16675542
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