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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3388
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkag1
Name: protein kinase AMP-activated non-catalytic subunit gamma 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkag1affects expressionISOPrkag1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of PRKAG1 mRNAPMID:21570461
Prkag1decreases expressionISOPrkag1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of PRKAG1 mRNAPMID:28213091
Prkag1multiple interactionsISOPrkag1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRKAG1 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PRKAG1 gene]PMID:17942748 PMID:28213091
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