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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3262
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pc
Name: pyruvate carboxylase
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pcaffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of PC mRNAPMID:22298810
Pcdecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of PC mRNA; Tetrachlorodibenzodioxin results in decreased expression of SLC35G3 mRNAPMID:16054898 PMID:18465118 PMID:21215274 PMID:21724226 PMID:32109520 PMID:33387578
Pcincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of PC mRNAPMID:33387578
Pcaffects expressionISOPC (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of PC mRNAPMID:22298810
Pcaffects expressionISOPcx (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of PCX mRNAPMID:21570461
Pcdecreases expressionISOPcx (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of PCX mRNAPMID:19770486 PMID:22539624
Pcincreases expressionISOPC (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of PC mRNAPMID:20106945 PMID:21632981 PMID:26238291
Pcmultiple interactionsISOPcx (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin affects the methylation of PCX intron] which results in decreased expression of PCX mRNA; Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PCX mRNA]PMID:16054899 PMID:33017471
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