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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2482
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of CYP7A1 mRNA

PMID:16054898, PMID:21215274
decreases expressionISORGD:104586480464CTDTetrachlorodibenzodioxin results in decreased expression of CYP7A1 mRNA

PMID:19770486, PMID:21846477, PMID:28213091
decreases expressionISORGD:692106480464CTDTetrachlorodibenzodioxin results in decreased expression of CYP7A1 mRNA

PMID:20106945
increases expressionISORGD:104586480464CTDTetrachlorodibenzodioxin results in increased expression of CYP7A1 mRNA

PMID:21095216
multiple interactionsISORGD:104586480464CTD[Tetrachlorodibenzodioxin co-treated with 2, 4, 5, 2', 4', 5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of CYP7A1 mRNA, [Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2, 4, 5, 2', 4', 5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of CYP7A1 mRNA, Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP7A1 gene]

PMID:23756648, PMID:28213091, PMID:28433925
multiple interactionsISORGD:692106480464CTD[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CYP7A1 mRNA

PMID:26159488
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.