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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2326
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cebpa
Name: CCAAT/enhancer binding protein alpha
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of CEBPA mRNA

PMID:22298810
decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of CEBPA mRNA

PMID:18796159, PMID:21215274
multiple interactionsEXP 6480464CTDherbimycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPA protein binds to CEBPB protein] which binds to PTGS2 promoter]], Tetrachlorodibenzodioxin results in increased activity of [[CEBPA protein binds to CEBPB protein] which binds to PTGS2 promoter]

PMID:11133817
affects expressionISORGD:103256480464CTDTetrachlorodibenzodioxin affects the expression of CEBPA mRNA

PMID:24058054
decreases expressionISORGD:103256480464CTDTetrachlorodibenzodioxin results in decreased expression of CEBPA mRNA, Tetrachlorodibenzodioxin results in decreased expression of CEBPA protein

PMID:12758056, PMID:14708085, PMID:16615095, PMID:20633992, PMID:26290441
decreases expressionISORGD:691216480464CTDTetrachlorodibenzodioxin results in decreased expression of CEBPA mRNA

PMID:20106945, PMID:21632981, PMID:26238291
increases expressionISORGD:103256480464CTDTetrachlorodibenzodioxin results in increased expression of CEBPA mRNA

PMID:15034205, PMID:16054899, PMID:17407152, PMID:21846477
increases expressionISORGD:691216480464CTDTetrachlorodibenzodioxin results in increased expression of CEBPA mRNA

PMID:28011154
multiple interactionsISORGD:103256480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CEBPA protein], [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPA mRNA], [Tetrachlorodibenzodioxin co-treated with EGF protein] results in decreased expression of CEBPA mRNA, CEBPA protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC2A4 mRNA], Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CEBPA mRNA], N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CEBPA mRNA], SRC protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CEBPA mRNA], Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPA mRNA], Tetrachlorodibenzodioxin inhibits the reaction [CEBPA protein binds to SLC2A4 promoter], Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of CEBPA mRNA], Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CEBPA gene]

PMID:12758056, PMID:14708085, PMID:15667827, PMID:16054899, PMID:16615095, PMID:17407152, PMID:21762485
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.