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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2153
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arnt
Name: aryl hydrocarbon receptor nuclear translocator
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTD[[Tetrachlorodibenzodioxin binds to AHR protein] which binds to ARNT protein] which binds to CYP1A1 enhancer, [Tetrachlorodibenzodioxin binds to AHR protein] which binds to ARNT protein

PMID:7808420, PMID:9056263
decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of ARNT mRNA

PMID:20959002, PMID:21215274
increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of ARNT mRNA, Tetrachlorodibenzodioxin results in increased expression of ARNT protein

PMID:12128104, PMID:28341572
increases phosphorylationEXP 6480464CTDTetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein

PMID:23298284
multiple interactionsEXP 6480464CTDARNT protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA], ARNT protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA], ARNT protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of FOXQ1 mRNA], ARNT protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of FST mRNA], arsenite inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [[AHR protein co-treated with ARNT protein] binds to CYP1A1 promoter]], arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of and results in increased localization of [AHR protein co-treated with ARNT protein]], Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1B1 enhancer], Tetrachlorodibenzodioxin promotes the reaction [[AHR protein co-treated with ARNT protein] binds to CYP1A1 promoter], Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein], Tetrachlorodibenzodioxin results in increased activity of and results in increased localization of [AHR protein co-treated with ARNT protein]

PMID:12859982, PMID:22159698, PMID:23196670, PMID:9056263
affects expressionISORGD:101896480464CTDTetrachlorodibenzodioxin affects the expression of ARNT mRNA

PMID:21570461, PMID:24058054
affects localizationISORGD:7327396480464CTDTetrachlorodibenzodioxin affects the localization of ARNT protein

PMID:25826687
affects response to substanceISORGD:101896480464CTDARNT protein affects the susceptibility to Tetrachlorodibenzodioxin

PMID:14530333, PMID:9624117
decreases expressionISORGD:101896480464CTDTetrachlorodibenzodioxin results in decreased expression of ARNT mRNA

PMID:10048155, PMID:24709672
decreases expressionISORGD:7327396480464CTDTetrachlorodibenzodioxin results in decreased expression of ARNT mRNA, Tetrachlorodibenzodioxin results in decreased expression of ARNT protein

PMID:15075337, PMID:9783729
increases activityISORGD:7327396480464CTDTetrachlorodibenzodioxin results in increased activity of ARNT protein

PMID:15982688
increases expressionISORGD:101896480464CTDTetrachlorodibenzodioxin results in increased expression of ARNT mRNA

PMID:15667827, PMID:19770486, PMID:21095216
increases expressionISORGD:7327396480464CTDTetrachlorodibenzodioxin results in increased expression of ARNT mRNA, Tetrachlorodibenzodioxin results in increased expression of ARNT protein

PMID:12727795, PMID:21998131, PMID:9787404
increases localizationISORGD:101896480464CTDTetrachlorodibenzodioxin results in increased localization of ARNT protein

PMID:14761680
increases phosphorylationISORGD:101896480464CTDTetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein

PMID:17880909
increases phosphorylationISORGD:7327396480464CTDTetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein

PMID:20450880
increases response to substanceISORGD:101896480464CTDARNT results in increased susceptibility to Tetrachlorodibenzodioxin

PMID:20935161
multiple interactionsISORGD:101896480464CTD3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]], [Tetrachlorodibenzodioxin binds to [AHR protein binds to ARNT protein]] which results in increased expression of CYP2A5 mRNA, [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]] which results in increased expression of JUN mRNA, [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]] which results in increased expression of JUND mRNA, Apigenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]], ARNT affects the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA], ARNT affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA], ARNT affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA], ARNT affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA], ARNT affects the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A6 mRNA], ARNT mutant form inhibits the reaction [[Tetrachlorodibenzodioxin analog co-treated with FGF2 protein] results in increased expression of DSG1A mRNA], ARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of H2-Q1 mRNA], ARNT protein affects the reaction [Tetrachlorodibenzodioxin results in increased activity of ENTPD2 protein], ARNT protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein], ARNT protein inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [PRL protein results in increased expression of CSN2 protein]], ARNT protein promotes the reaction [Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]], ARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNA], ARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein], ARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINE1 mRNA], ARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINE1 protein], ARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA], Curcumin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]], Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]], Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein], epigallocatechin gallate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]], kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]], MAP2K1 protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein modified form binds to ARNT protein modified form]], MAP2K1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein modified form co-treated with ARNT protein modified form]], MAP2K2 protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein modified form binds to ARNT protein modified form]], MAP2K2 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein modified form co-treated with ARNT protein modified form]], naringenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]], Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [ARNT protein binds to FOS promoter]], Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter], Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CXCL5 promoter], Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer], Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP2S1 promoter], Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to FGF21 promoter], Tetrachlorodibenzodioxin promotes the reaction [[AHR protein co-treated with ARNT protein] binds to CYP1A1 enhancer], Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein], Tetrachlorodibenzodioxin promotes the reaction [AHR protein modified form binds to ARNT protein modified form], Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 5' UTR], Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter], Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to FMO3 enhancer], Tetrachlorodibenzodioxin promotes the reaction [CHUK protein binds to AHR protein binds to ARNT protein], Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein], Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein], Tetrachlorodibenzodioxin results in increased activity of [AHR protein modified form co-treated with ARNT protein modified form], U 0126 inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein modified form binds to ARNT protein modified form]], U 0126 inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein modified form co-treated with ARNT protein modified form]], Ursodeoxycholic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of ARNT protein]

PMID:10581206, PMID:10692565, PMID:10871357, PMID:11043581, PMID:11606800, PMID:12111005, PMID:12139968, PMID:12147270, PMID:12237327, PMID:12644593, PMID:12859983, PMID:12917420, PMID:14761680, PMID:15364539, PMID:15657367, PMID:16226227, PMID:17277313, PMID:17880909, PMID:17991765, PMID:18765683, PMID:20450880, PMID:20935161, PMID:21889950, PMID:23212921, PMID:24519526, PMID:25265996, PMID:26259605, PMID:27226639, PMID:28973351, PMID:7791778, PMID:7828219, PMID:8524325, PMID:8917696, PMID:9368027, PMID:9624117
multiple interactionsISORGD:7327396480464CTD3, 3', 4, 5'-tetrahydroxystilbene inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]], 3, 3', 4, 5'-tetrahydroxystilbene inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]], [Tetrachlorodibenzodioxin binds to and results in increased activity of [AHR protein binds to ARNT protein]] inhibits the reaction [Estradiol results in increased expression of CTSD mRNA], [Tetrachlorodibenzodioxin co-treated with Tretinoin] results in decreased expression of ARNT mRNA, AHR gene mutant form inhibits the reaction [Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to TFF1 promoter]]], AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to TFF1 promoter]], AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [ARNT protein binds to TFF1 promoter]]], Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein], ARNT gene mutant form inhibits the reaction [Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GREB1 promoter]]], ARNT gene mutant form inhibits the reaction [Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TFF1 promoter]]], ARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GREB1 promoter]], ARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TFF1 promoter]], ARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [AHR protein binds to CYP1B1 promoter]]], ARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [AHR protein binds to GREB1 promoter]]], ARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [AHR protein binds to TFF1 promoter]]], ARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of ESR1 protein]], ARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA], ARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA], ARNT mutant form inhibits the reaction [[IL1B protein co-treated with Tetrachlorodibenzodioxin] results in increased expression of IL6 mRNA], ARNT mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA], ARNT protein affects the reaction [Tetrachlorodibenzodioxin promotes the reaction [BRCA1 protein binds to CYP1B1 promoter]], ARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH1A mRNA], ARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH1B mRNA], ARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 mRNA], ARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 protein], ARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH6 mRNA], ARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of NPC1 protein], ARNT protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA], ARNT protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CTSD mRNA]], ARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP2E1 mRNA], epigallocatechin gallate inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein], Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]], Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]], Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to TFF1 promoter]], kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]], kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]], kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]], kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]], kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein], naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein], NCOA1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]], NCOA2 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]], NCOA3 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]], Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]], Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]], Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]], Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]], Tetrachlorodibenzodioxin binds to and results in increased activity of [AHR protein binds to ARNT protein], Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CTSD promoter], Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer], Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 promoter], Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1B1 enhancer], Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which results in decreased expression of CTSD mRNA], Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA], Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein], Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer], Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 gene], Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter], Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer], Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 gene], Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter], Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to HSPB8 promoter], Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to TFF1 promoter], Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to TIPARP promoter], Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to TSKU promoter], Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to UGT1A1 promoter], Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [ARNT protein binds to CYP1B1 promoter]], Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [ARNT protein binds to TFF1 promoter]], Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]

PMID:11165043, PMID:11294989, PMID:11368516, PMID:12024042, PMID:12801909, PMID:15075337, PMID:15313166, PMID:16399344, PMID:16567799, PMID:16675542, PMID:16972788, PMID:17599377, PMID:17823304, PMID:18541696, PMID:19131362, PMID:19147701, PMID:19376845, PMID:20450880, PMID:20511231, PMID:20846786, PMID:21703235, PMID:22071320, PMID:22235307, PMID:24299737, PMID:24806346, PMID:27055685, PMID:27226639, PMID:28673560, PMID:29274782, PMID:8397410
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.