GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Aqp8 | affects expression | ISO | Aqp8 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of AQP8 mRNA | PMID:21570461 PMID:26377647 | Aqp8 | decreases expression | ISO | Aqp8 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of AQP8 mRNA | PMID:28213091 PMID:28922406 | Aqp8 | multiple interactions | ISO | Aqp8 (Mus musculus) | 6480464 | CTD | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AQP8 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of AQP8 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to AQP8 gene] | PMID:17942748 PMID:25975270 PMID:28213091 | |
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