GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Alpl | decreases activity | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased activity of ALPL protein | PMID:11018766 | Alpl | multiple interactions | EXP | | 6480464 | CTD | resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased activity of ALPL protein]; resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL mRNA] | PMID:11018766 | Alpl | affects expression | ISO | ALPL (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of ALPL mRNA | PMID:20106945 PMID:36370075 | Alpl | affects expression | ISO | Alpl (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of ALPL mRNA | PMID:26377647 | Alpl | decreases expression | ISO | Alpl (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of ALPL mRNA; Tetrachlorodibenzodioxin results in decreased expression of ALPL protein | PMID:22749964 PMID:25194622 PMID:25795401 PMID:26290441 PMID:28836330 PMID:33956508 PMID:34363983 | Alpl | increases activity | ISO | ALPL (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased activity of ALPL protein | PMID:30203000 | Alpl | increases expression | ISO | ALPL (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of ALPL mRNA; Tetrachlorodibenzodioxin results in increased expression of ALPL protein | PMID:18724896 PMID:30203000 | Alpl | multiple interactions | ISO | Alpl (Mus musculus) | 6480464 | CTD | 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL mRNA]; actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL mRNA]; actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL protein]; tributyltin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL mRNA] | PMID:22749964 PMID:25194622 PMID:28836330 | | ||||||||||||||||||||||
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