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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2091
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldoc
Name: aldolase, fructose-bisphosphate C
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldocincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of ALDOC mRNAPMID:32109520
Aldocaffects expressionISOAldoc (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of ALDOA mRNA; Tetrachlorodibenzodioxin affects the expression of ALDOC mRNAPMID:21570461
Aldocdecreases expressionISOAldoc (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of ALDOA mRNA; Tetrachlorodibenzodioxin results in decreased expression of ALDOC mRNAPMID:15667827 PMID:19770486
Aldocdecreases expressionISOALDOC (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of ALDOC mRNAPMID:20106945 PMID:23152189
Aldocincreases expressionISOAldoc (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of ALDOA mRNA; Tetrachlorodibenzodioxin results in increased expression of ALDOC mRNAPMID:16922920 PMID:19770486
Aldocmultiple interactionsISOAldoc (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALDOA mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALDOC mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ALDOC promoter]PMID:17942748 PMID:19654925
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