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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1620890
Species: Mus musculus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP-binding cassette, sub-family B member 1A
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aaffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of ABCB1A mRNAPMID:26377647 PMID:28922406
Abcb1adecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of ABCB1A mRNAPMID:17942748 PMID:19770486
Abcb1amultiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin affects the methylation of ABCB1A enhancer] which results in decreased expression of ABCB1A mRNA; [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ABCB1A mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of ABCB1A mRNAPMID:17942748 PMID:28433925 PMID:33017471
Abcb1adecreases expressionISOAbcb1a (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of ABCB1A mRNAPMID:18796159 PMID:21215274 PMID:22808131 PMID:28341572 PMID:34747641
Abcb1aincreases expressionISOAbcb1a (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of ABCB1A mRNA; Tetrachlorodibenzodioxin results in increased expression of ABCB1A proteinPMID:21048045 PMID:33387578
Abcb1aincreases expressionISOABCB1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of ABCB1 mRNAPMID:16837569 PMID:20106945 PMID:21632981 PMID:26238291
Abcb1amultiple interactionsISOAbcb1a (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of and results in increased activity of ABCB1 proteinPMID:22472606
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