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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1607086
Species: Homo sapiens
RGD Object: Gene
Symbol: SKP2
Name: S-phase kinase associated protein 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SKP2decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of SKP2 mRNAPMID:20106945 PMID:21632981
SKP2affects expressionISOSkp2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of SKP2 mRNAPMID:21570461
SKP2increases expressionISOSkp2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of SKP2 mRNAPMID:19465110
SKP2multiple interactionsISOSkp2 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SKP2 mRNAPMID:17942748
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