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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1596791
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hist4h4
Name: histone cluster 4, H4
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of HIST4H4 protein

PMID:16548065
affects expressionISORGD:16197096480464CTDTetrachlorodibenzodioxin affects the expression of HIST4H4 mRNA

PMID:21570461, PMID:26377647
multiple interactionsISORGD:13467036480464CTDTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased acetylation of HIST4H4 promoter], Tetrachlorodibenzodioxin promotes the reaction [HIST4H4 protein modified form binds to PTGS2 promoter]

PMID:16489025, PMID:19056653
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.