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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1595491
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tbc1d8
Name: TBC1 domain family, member 8
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tbc1d8increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of TBC1D8 mRNAPMID:21215274 PMID:32109520 PMID:33387578
Tbc1d8affects expressionISOTbc1d8 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of TBC1D8 mRNAPMID:21570461 PMID:26377647
Tbc1d8increases expressionISOTBC1D8 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of TBC1D8 mRNAPMID:20106945 PMID:21632981
Tbc1d8increases expressionISOTbc1d8 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of TBC1D8 mRNAPMID:19770486 PMID:19933214 PMID:21889950 PMID:25975270 PMID:26290441
Tbc1d8multiple interactionsISOTbc1d8 (Mus musculus)6480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of TBC1D8 mRNAPMID:25975270
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