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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1594556
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnfaip2
Name: TNF alpha induced protein 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of TNFAIP2 mRNA

PMID:22298810
affects expressionISORGD:13122346480464CTDTetrachlorodibenzodioxin affects the expression of TNFAIP2 mRNA

PMID:22298810
affects expressionISORGD:13122356480464CTDTetrachlorodibenzodioxin affects the expression of TNFAIP2 mRNA

PMID:18343893, PMID:21570461, PMID:26377647
increases expressionISORGD:13122346480464CTDTetrachlorodibenzodioxin results in increased expression of TNFAIP2 mRNA

PMID:19692669
increases expressionISORGD:13122356480464CTDTetrachlorodibenzodioxin results in increased expression of TNFAIP2 mRNA

PMID:15328365, PMID:15800033, PMID:16611356, PMID:18796159, PMID:19770486, PMID:19933214, PMID:21851831, PMID:21889950, PMID:21995607, PMID:23994337, PMID:26290441
multiple interactionsISORGD:13122356480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of TNFAIP2 mRNA, [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TNFAIP2 mRNA, [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of TNFAIP2 mRNA, AHR affects the reaction [Tetrachlorodibenzodioxin results in increased expression of TNFAIP2 mRNA]

PMID:16214954, PMID:17942748, PMID:21995607, PMID:25975270
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.