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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1565000
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fabp12
Name: fatty acid binding protein 12
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fabp12affects expressionISOFabp12 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of FABP12 mRNAPMID:26377647
Fabp12increases expressionISOFabp12 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of FABP12 mRNAPMID:21851831 PMID:25975270 PMID:26290441 PMID:28238261
Fabp12multiple interactionsISOFabp12 (Mus musculus)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FABP12 mRNA]; [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of FABP12 mRNA; [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of FABP12 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of FABP12 mRNA; Tetrachlorodibenzodioxin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of FABP12 mRNA]PMID:16214954 PMID:21851831 PMID:25975270 PMID:28433925
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