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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1561519
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnfsf13b
Name: TNF superfamily member 13b
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfsf13bdecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of TNFSF13B mRNAPMID:32109520
Tnfsf13bmultiple interactionsISOTNFSF13B (Homo sapiens)6480464CTD[Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in increased expression of TNFSF13B mRNA; Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to RELB protein] which binds to TNFSF13B promoter]PMID:17900530
Tnfsf13bmultiple interactionsISOTnfsf13b (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased expression of TNFSF13B mRNAPMID:21131560
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