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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1558014
Species: Mus musculus
RGD Object: Gene
Symbol: Sox2
Name: SRY (sex determining region Y)-box 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sox2affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of SOX2 mRNA; Tetrachlorodibenzodioxin affects the expression of SOX2 proteinPMID:21570461 PMID:24058054 PMID:36029422
Sox2increases expressionISOSOX2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of SOX2 mRNAPMID:30203000
Sox2multiple interactionsISOSOX2 (Homo sapiens)6480464CTDN-(2-(3H-indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)purin-6-amine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOX2 mRNA]PMID:30203000
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