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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1557103
Species: Mus musculus
RGD Object: Gene
Symbol: Tnfaip8l1
Name: tumor necrosis factor, alpha-induced protein 8-like 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfaip8l1affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of TNFAIP8L1 mRNAPMID:20702594 PMID:26377647
Tnfaip8l1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of TNFAIP8L1 mRNAPMID:16214954 PMID:19770486 PMID:21851831 PMID:21889950 PMID:25975270 PMID:26290441
Tnfaip8l1multiple interactionsEXP 6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TNFAIP8L1 mRNA]; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of TNFAIP8L1 mRNA; AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of TNFAIP8L1 mRNA]PMID:16214954 PMID:21851831 PMID:25975270
Tnfaip8l1decreases expressionISOTnfaip8l1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of TNFAIP8L1 mRNAPMID:32109520 PMID:33387578
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