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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1553310
Species: Mus musculus
RGD Object: Gene
Symbol: Whrn
Name: whirlin
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Whrnmultiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of WHRN mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to WHRN promoter]PMID:17942748 PMID:19654925
Whrnaffects expressionISOWHRN (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of WHRN mRNAPMID:22298810
Whrnaffects expressionISOWhrn (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of WHRN mRNAPMID:22298810
Whrndecreases expressionISOWhrn (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of WHRN mRNAPMID:33387578
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