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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1553186
Species: Mus musculus
RGD Object: Gene
Symbol: Wdr74
Name: WD repeat domain 74
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Wdr74affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of WDR74 mRNA

PMID:21570461
Wdr74decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of WDR74 mRNA

PMID:21354282
Wdr74decreases expressionISORGD:16033956480464CTDTetrachlorodibenzodioxin results in decreased expression of WDR74 mRNA

PMID:29704546
Wdr74multiple interactionsISORGD:16033956480464CTD[Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in decreased expression of WDR74 mRNA

PMID:29704546
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.