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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551902
Species: Mus musculus
RGD Object: Gene
Symbol: Dgat2
Name: diacylglycerol O-acyltransferase 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dgat2affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of DGAT2 mRNAPMID:21570461 PMID:26377647
Dgat2decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of DGAT2 mRNAPMID:21846477 PMID:22977169 PMID:27713108 PMID:28213091 PMID:28238261
Dgat2increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of DGAT2 mRNAPMID:22539624
Dgat2multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in increased expression of DGAT2 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Dietary Fats results in increased expression of DGAT2 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [NFE2L2 gene mutant form results in decreased expression of DGAT2 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to DGAT2 gene]PMID:21846477 PMID:23756648 PMID:27713108 PMID:28213091
Dgat2affects expressionISODgat2 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of DGAT2 mRNAPMID:22298810
Dgat2decreases expressionISODGAT2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of DGAT2 mRNAPMID:20106945 PMID:21632981
Dgat2decreases expressionISODgat2 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of DGAT2 mRNAPMID:21215274
Dgat2increases expressionISODgat2 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of DGAT2 mRNAPMID:33387578
Dgat2multiple interactionsISODGAT2 (Homo sapiens)6480464CTD[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DGAT2 mRNAPMID:26159488
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