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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551109
Species: Mus musculus
RGD Object: Gene
Symbol: Smpdl3a
Name: sphingomyelin phosphodiesterase, acid-like 3A
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smpdl3amultiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMPDL3A mRNAPMID:17942748
Smpdl3aaffects expressionISOSmpdl3a (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of SMPDL3A mRNAPMID:34747641
Smpdl3adecreases expressionISOSMPDL3A (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of SMPDL3A mRNAPMID:20106945 PMID:21632981
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