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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551095
Species: Mus musculus
RGD Object: Gene
Symbol: Rela
Name: v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relaaffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of RELA mRNAPMID:21570461
Relaaffects localizationEXP 6480464CTDTetrachlorodibenzodioxin affects the localization of RELA proteinPMID:15972635 PMID:18172886 PMID:21846477 PMID:28302560
Relaincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of RELA mRNAPMID:11804338 PMID:11879969 PMID:24058054
Relamultiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of RELA protein]; AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of [NFKB1 protein binds to RELA protein]]; CYP1A1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of [NFKB1 protein binds to RELA protein]]; KL protein inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]]; Lipopolysaccharides promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [RELA protein binds to IGH enhancer]]; RELA mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; RELA mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; RELA protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of FASL protein]; Tacrolimus inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of RELA protein]; Tetrachlorodibenzodioxin inhibits the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased activity of RELA protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased activity of RELA protein]; Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; Tetrachlorodibenzodioxin inhibits the reaction [NFE2L2 gene mutant form affects the localization of RELA protein]; Tetrachlorodibenzodioxin inhibits the reaction [TNF protein results in increased localization of RELA protein]; Tetrachlorodibenzodioxin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]; Tetrachlorodibenzodioxin promotes the reaction [RELA protein binds to IGH enhancer]; Tetrachlorodibenzodioxin results in increased activity of [RELA protein co-treated with NFKB1 protein]PMID:10692565 PMID:12181450 PMID:15972635 PMID:18172886 PMID:20350561 PMID:21097750 PMID:21846477 PMID:24302727 PMID:26377645 PMID:28302560 PMID:29885354
Relaincreases expressionISORela (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of RELA mRNAPMID:34747641
Relamultiple interactionsISORELA (Homo sapiens)6480464CTD[IL1B protein co-treated with Tetrachlorodibenzodioxin] promotes the reaction [RELA protein modified form binds to IL6 promoter]; [IL1B protein co-treated with Tetrachlorodibenzodioxin] results in increased acetylation of RELA proteinPMID:20511231
Relamultiple interactionsISORela (Rattus norvegicus)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and affects the localization of RELA protein]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and affects the localization of RELA protein]; Tetrachlorodibenzodioxin results in increased phosphorylation of and affects the localization of RELA proteinPMID:23583884
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