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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1351494
Species: Homo sapiens
RGD Object: Gene
Symbol: TOP1MT
Name: DNA topoisomerase I mitochondrial
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TOP1MTaffects expressionISOTop1mt (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of TOP1MT mRNAPMID:21570461
TOP1MTincreases expressionISOTop1mt (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of TOP1MT mRNAPMID:33387578
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