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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350859
Species: Homo sapiens
RGD Object: Gene
Symbol: KRAS
Name: KRAS proto-oncogene, GTPase
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KRASaffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of KRAS mRNAPMID:22298810
KRASincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of KRAS mRNAPMID:11007951 PMID:20106945 PMID:21632981
KRASmultiple interactionsEXP 6480464CTDCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of KRAS mRNA]PMID:11007951
KRASaffects expressionISOKras (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of KRAS mRNAPMID:21570461
KRASdecreases expressionISOKras (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of KRAS mRNAPMID:14708085
KRASdecreases expressionISOKras (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of KRAS mRNAPMID:33387578
KRASincreases expressionISOKras (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of KRAS mRNAPMID:19465110
KRASincreases expressionISOKras (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of KRAS mRNAPMID:32109520
KRASmultiple interactionsISOKras (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KRAS mRNA; Tetrachlorodibenzodioxin promotes the reaction [Dimethylnitrosamine affects the localization of KRAS protein]; Tetrachlorodibenzodioxin promotes the reaction [Dimethylnitrosamine results in decreased expression of KRAS protein]; Tetrachlorodibenzodioxin results in increased expression of and affects the localization of KRAS proteinPMID:11884234 PMID:17942748 PMID:19555203 PMID:9525281
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