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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348134
Species: Homo sapiens
RGD Object: Gene
Symbol: IL3RA
Name: interleukin 3 receptor subunit alpha
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL3RAdecreases methylationISOIl3ra (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased methylation of IL3RA genePMID:21212295
IL3RAincreases expressionISOIl3ra (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of IL3RA mRNAPMID:32109520 PMID:33387578 PMID:34747641
IL3RAmultiple interactionsISOIl3ra (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of IL3RA genePMID:21212295
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