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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1343747
Species: Homo sapiens
RGD Object: Gene
Symbol: JAM2
Name: junctional adhesion molecule 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
JAM2affects expressionISOJam2 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of JAM2 mRNAPMID:34747641
JAM2affects expressionISOJam2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of JAM2 mRNAPMID:26377647
JAM2increases expressionISOJam2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of JAM2 mRNAPMID:19465110 PMID:19770486
JAM2multiple interactionsISOJam2 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of JAM2 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of JAM2 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to JAM2 promoter]PMID:17942748 PMID:19654925 PMID:25975270
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