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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1332089
Species: Mus musculus
RGD Object: Gene
Symbol: Aldh1a1
Name: aldehyde dehydrogenase family 1, subfamily A1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh1a1affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of ALDH1A1 mRNAPMID:21570461 PMID:26377647
Aldh1a1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of ALDH1A1 mRNAPMID:28213091
Aldh1a1multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with AHR protein mutant form] results in decreased expression of ALDH1A1 mRNAPMID:22496397
Aldh1a1decreases expressionISOAldh1a1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of ALDH1A1 mRNAPMID:18796159 PMID:21215274 PMID:21724226
Aldh1a1increases expressionISOAldh1a1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of ALDH1A1 mRNAPMID:32109520
Aldh1a1increases expressionISOALDH1A1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of ALDH1A1 mRNAPMID:20106945 PMID:21632981
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