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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1322558
Species: Mus musculus
RGD Object: Gene
Symbol: Twsg1
Name: twisted gastrulation BMP signaling modulator 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Twsg1affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of TWSG1 mRNAPMID:21570461
Twsg1multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of TWSG1 mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TWSG1 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of TWSG1 mRNAPMID:16214954 PMID:17942748 PMID:25975270
Twsg1affects expressionISOTwsg1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of TWSG1 mRNAPMID:34747641
Twsg1decreases expressionISOTwsg1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of TWSG1 mRNAPMID:33387578
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