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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1319618
Species: Mus musculus
RGD Object: Gene
Symbol: Lrp5
Name: low density lipoprotein receptor-related protein 5
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lrp5affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of LRP5 mRNAPMID:21570461 PMID:28922406 PMID:36222588
Lrp5affects expressionISOLrp5 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of LRP5 mRNAPMID:22298810
Lrp5decreases expressionISOLrp5 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of LRP5 mRNAPMID:21215274
Lrp5increases expressionISOLrp5 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of LRP5 mRNAPMID:34747641
Lrp5increases expressionISOLRP5 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of LRP5 mRNAPMID:19619570 PMID:20106945 PMID:21632981 PMID:26238291 PMID:28011154 PMID:36370075
Lrp5multiple interactionsISOLRP5 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LRP5 mRNAPMID:19619570
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