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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318780
Species: Homo sapiens
RGD Object: Gene
Symbol: CSK
Name: C-terminal Src kinase
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of CSK mRNA

PMID:21802500, PMID:23152189
affects expressionISORGD:13088006480464CTDTetrachlorodibenzodioxin affects the expression of CSK mRNA

PMID:22298810
increases expressionISORGD:13088006480464CTDTetrachlorodibenzodioxin results in increased expression of CSK mRNA

PMID:18796159
increases response to substanceISORGD:13187816480464CTDCSK protein results in increased susceptibility to Tetrachlorodibenzodioxin

PMID:9664232
multiple interactionsISORGD:13187816480464CTDCSK protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]], CSK protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine binds to THRA protein]], CSK protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of FOS protein], CSK protein promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK1 protein], CSK protein promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein], geldanamycin inhibits the reaction [CSK protein results in increased susceptibility to Tetrachlorodibenzodioxin], geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]], Tetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]

PMID:9664232
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.