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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1316883
Species: Mus musculus
RGD Object: Gene
Symbol: Fbxo8
Name: F-box protein 8
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of FBXO8 mRNA

PMID:21570461
multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of FBXO8 mRNA

PMID:16214954
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.