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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315695
Species: Homo sapiens
RGD Object: Gene
Symbol: AKR1C1
Name: aldo-keto reductase family 1 member C1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKR1C1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of AKR1C1 mRNAPMID:19619570
AKR1C1multiple interactionsEXP 6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AKR1C1 mRNAPMID:19619570
AKR1C1affects expressionISOAkr1c1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of AKR1C1 mRNAPMID:22298810
AKR1C1decreases expressionISOAkr1c1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of AKR1C1 mRNA; Tetrachlorodibenzodioxin results in decreased expression of AKR1C6 mRNAPMID:18796159 PMID:21215274
AKR1C1decreases expressionISOAkr1c20 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of AKR1C20 mRNAPMID:20005886 PMID:21851831 PMID:25975270
AKR1C1multiple interactionsISOAkr1c20 (Mus musculus)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of AKR1C20 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of AKR1C20 mRNA]PMID:21851831
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