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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315573
Species: Homo sapiens
RGD Object: Gene
Symbol: TPD52
Name: tumor protein D52
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TPD52affects expressionISOTpd52 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of TPD52 mRNAPMID:21570461
TPD52decreases expressionISOTpd52 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of TPD52 mRNAPMID:34747641
TPD52increases expressionISOTpd52 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of TPD52 mRNAPMID:20959002 PMID:21215274 PMID:32109520
TPD52multiple interactionsISOTpd52 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TPD52 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of TPD52 mRNAPMID:17942748 PMID:25975270
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