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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315104
Species: Mus musculus
RGD Object: Gene
Symbol: Pik3cg
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pik3cgdecreases expressionISOPIK3CG (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of PIK3CG mRNAPMID:11007951
Pik3cgincreases expressionISOPik3cg (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of PIK3CG mRNAPMID:32109520 PMID:34747641
Pik3cgmultiple interactionsISOPIK3CG (Homo sapiens)6480464CTDCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PIK3CG mRNA]PMID:11007951
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