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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313358
Species: Homo sapiens
RGD Object: Gene
Symbol: SOX17
Name: SRY-box transcription factor 17
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOX17affects expressionISOSox17 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of SOX17 mRNAPMID:26377647
SOX17decreases expressionISOSox17 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of SOX17 mRNAPMID:34747641
SOX17increases expressionISOSox17 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of SOX17 mRNAPMID:33387578
SOX17increases expressionISOSox17 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of SOX17 mRNAPMID:19770486 PMID:24058054
SOX17multiple interactionsISOSox17 (Mus musculus)6480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of SOX17 mRNAPMID:25975270
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