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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313158
Species: Homo sapiens
RGD Object: Gene
Symbol: PLEKHA3
Name: pleckstrin homology domain containing A3
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PLEKHA3affects expressionISORGD:13131596480464CTDTetrachlorodibenzodioxin affects the expression of PLEKHA3 mRNA

PMID:21570461
PLEKHA3increases expressionISORGD:13131596480464CTDTetrachlorodibenzodioxin results in increased expression of PLEKHA3 mRNA

PMID:15034205
PLEKHA3multiple interactionsISORGD:13131596480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLEKHA3 mRNA, AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLEKHA3 mRNA]

PMID:15034205, PMID:17942748
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.