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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1312024
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Irf8
Name: interferon regulatory factor 8
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Irf8affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of IRF8 mRNAPMID:34747641
Irf8increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of IRF8 mRNAPMID:32109520 PMID:33387578
Irf8affects expressionISOIrf8 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of IRF8 mRNAPMID:21570461 PMID:24058054 PMID:26377647
Irf8increases expressionISOIrf8 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of IRF8 mRNAPMID:21851831
Irf8multiple interactionsISOIrf8 (Mus musculus)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IRF8 mRNA]PMID:21851831
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