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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1312011
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Shmt1
Name: serine hydroxymethyltransferase 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Shmt1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of SHMT1 mRNAPMID:21215274 PMID:32109520
Shmt1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of SHMT1 mRNAPMID:33387578
Shmt1affects expressionISOSHMT1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of SHMT1 mRNAPMID:22298810 PMID:22574217
Shmt1affects expressionISOShmt1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of SHMT1 mRNAPMID:26377647
Shmt1decreases expressionISOSHMT1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of SHMT1 mRNAPMID:20106945
Shmt1decreases expressionISOShmt1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of SHMT1 mRNAPMID:19770486 PMID:26290441
Shmt1multiple interactionsISOShmt1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SHMT1 mRNAPMID:17942748
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