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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311104
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nceh1
Name: neutral cholesterol ester hydrolase 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nceh1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of NCEH1 mRNAPMID:32109520 PMID:33387578
Nceh1affects expressionISONceh1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of NCEH1 mRNAPMID:21570461 PMID:26377647
Nceh1multiple interactionsISONceh1 (Mus musculus)6480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of NCEH1 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NCEH1 promoter]PMID:19654925 PMID:25975270
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