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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311050
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mbd6
Name: methyl-CpG binding domain protein 6
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mbd6decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of MBD6 mRNAPMID:21215274
Mbd6multiple interactionsEXP 6480464CTDAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of MBD6 mRNA]PMID:21215274
Mbd6affects expressionISOMbd6 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of MBD6 mRNAPMID:21570461
Mbd6decreases expressionISOMbd6 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of MBD6 mRNAPMID:26290441
Mbd6increases expressionISOMbd6 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of MBD6 mRNAPMID:31511937
Mbd6multiple interactionsISOMbd6 (Mus musculus)6480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to MBD6 promoter]PMID:19654925
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