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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310981
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Trim2
Name: tripartite motif-containing 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Trim2decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of TRIM2 mRNAPMID:21215274 PMID:22808131 PMID:34747641
Trim2increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of TRIM2 mRNAPMID:33387578
Trim2affects expressionISOTrim2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of TRIM2 mRNAPMID:21570461 PMID:28922406
Trim2multiple interactionsISOTrim2 (Mus musculus)6480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of TRIM2 mRNAPMID:25975270
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