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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309289
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nthl1
Name: nth-like DNA glycosylase 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of NTHL1 mRNA

PMID:21215274
affects expressionISORGD:13195556480464CTDTetrachlorodibenzodioxin affects the expression of NTHL1 mRNA

PMID:21570461
decreases expressionISORGD:13195546480464CTDTetrachlorodibenzodioxin results in decreased expression of NTHL1 mRNA

PMID:19684285
multiple interactionsISORGD:13195556480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NTHL1 mRNA

PMID:17942748
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.